Osama Mohamad; MD/PhD Graduate Student
I study the therapeutic potential of mouse and human embryonic and induced pluripotent stem cells in the treatment of ischemic stroke. Before being taken to the clinic for use in human subjects, it is of great significance to study the mechanism of action of stem cells after transplantation and whether their therapeutic benefit is due to trophic support or they do participate in neural functions. I am also trying to develop a neuronal differentiation protocol of mouse pluripotent cells with higher efficiency. Ultimately, I want to investigate whether the transplanted ES cell-derived neural stem (NS) cells functionally integrate within the established host brain neuronal circuits. I also aim to test whether whisker stimulation (the equivalent to physical therapy in our model) enhances functional outcomes.